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PRODID:-//University of Iceland//AI Centre//EN
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BEGIN:VEVENT
UID:4b0df1ff-553b-4d65-b33f-e1953552c73c@ai.hi.is
DTSTAMP:20261011T043457Z
DTSTART:20260120T090000Z
DTEND:20260120T100000Z
SUMMARY:DNA methylation analysis using long-read sequencing
DESCRIPTION:Beyond the primary genetic code\, DNA carries a second layer of
  information in the form of epigenetic modifications\, predominantly DNA m
 ethylation. DNA methylation is a dynamic process involved in gene regulati
 on\, aging\, and disease\, yet its genome-wide and allele-specific regulat
 ion has been difficult to resolve with traditional technologies. Using lon
 g-read sequencing\, we investigate how genetic variation and aging shape t
 he human methylome with parent-of-origin resolution. We show that much of 
 the observed correlation between DNA methylation and gene expression is dr
 iven by underlying DNA sequence variants. We further identify widespread a
 ge-associated methylation changes across the genome and develop a highly a
 ccurate methylation aging clock. Finally\, by resolving methylation to par
 ental haplotypes\, we uncover parent-of-origin–specific aging effects co
 ncentrated at imprinted loci\, indicating erosion of imprinting fidelity w
 ith age.\n\nhttps://ai.hi.is/is/events/colloquium-in-statistics-and-ai-7/
LOCATION:Íslensk erfðagreining\, Tjarnarsalur
URL:https://ai.hi.is/is/events/colloquium-in-statistics-and-ai-7/
STATUS:CONFIRMED
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