Organ-specific ageing from plasma proteomics

Ageing is a risk factor for many major chronic diseases. This decline does not happen uniformly over the body and inter-individual variability is substantial. Biological age based on biomarkers can be used to estimate differences in ageing between individuals while organ age aims to capture the variability in ageing between organs. In a large plasma proteomics dataset from the UK Biobank, we estimate protein-derived organ age for multiple organs. We explore how the differences between chronological age and estimated organ ages associate with diverse health outcomes, look at shared and organ-specific ageing, and compare with MRI-derived brain age and disease risk scores.